The reception and influence of Popper’s philosophy of science and his political philosophy in Latin America have depended heavily on the translation of his major works originally published in German and English. Thus, for example, The Logic of Scientific Discovery, which was originally published in 1959, was translated into Spanish in 1962 and into Portuguese only in 1974. Similarly, The Open Society and Its Enemies, originally published in 1945, was translated into Spanish twelve years later in 1957 and into Portuguese in 1974. But apart from a discussion of the impact of the translations of his books, I also want to show that the political situation in some Latin American countries, for example, Chile, Cuba and Peru, has played a very important role in the introduction, reception and influence of Popper’s philosophy of science in general and his social and political thought in particular. Accordingly, the main purpose of this article is to examine the reception of Popper’s ideas in Latin America and give an account of his influence and legacy in some of the Latin American countries such as Argentina, Brazil, Chile, Colombia, Cuba, Mexico, Peru and Uruguay.